Alcohol consumption and liver disease

<h2 id="aim">Aim</h2><p>This study aimed to explain dose-dependent correlation between alcohol use and<br>progression of SLD using a noninvasive, low-cost method.</p><h2 id="design">Study Design</h2><ul><li>Cohort study,data from the US National Health and Nutrition Examination Survey Ill<br>(1988-1994) database, followed through December 31, 2019 was obtained.</li><li>2834 individuals with confirmed SLD were divided into 2 groups :<ul><li>Group A: (n = 2243) Low risk for advanced fibrosis</li><li>Group B: (n = 591)lntermediate or high risk for advanced fibrosis</li></ul></li><li>SLD was defined as ultrasonography-confirmed hepatic steatosis. An intermediate or<br>high risk for advanced fibrosis was defined by a Fibrosis-4 index (FIB-4) score of 1.3 or<br>higher.</li></ul><h2 id="results">Results</h2><ul><li>Out of 2834 individuals with SLD, 20.8% (n = 591) had intermediate or high risk of<br>advanced fibrosis, with higher prevalence of metabolic disorders and a male<br>predominance.</li><li>During median follow-up of 26 years, it was observed that individuals with<br>intermediate or high risk for advanced fibrosis experienced a mortality rate of 4,342 per<br>100,000 persons. In contrast, low-risk group exhibited a significantly lower mortality<br>rate of 1,099 per 100,000 persons.</li><li>Mortality risk exceeded an adjusted hazard ratio of 1.00 at a 7.4-g daily intake (Figure, A). After adjustment for demographics and metabolic variables, there was a nonlinear<br>association between alcohol intake and mortality in the low-risk group (P = .001 for<br>nonlinearity).</li><li>In the intermediate- or high-risk group, a linear association between daily alcohol<br>consumption and increased risk of mortality was observed (Figure, B).</li></ul><p style="text-align:center;"><img src="https://cdn.megawecare.com/GHBY/Internal-Images/daily_alcolol_comsum.png" width="876" height="500"></p><ul><li>In the low-risk group, the mortality risk threshold was &lt; 7.4 g/d, which equals half a 12-<br>oz beer or half a glass of wine. Each additional gram above this level led to a higher death<br>rate.</li><li>No safe alcohol limit was evident in the intermediate- and high-risk group; their mortality<br>risk rose with any alcohol intake.</li></ul>

GASTRO UPDATES 2024  Final

<ul><li><a href="#aim">Aim</a></li><li><a href="#design">Study Design</a></li><li><a href="#results">Results</a></li></ul>

Alcohol consumption and liver disease

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